EFSA is tasked with coordinating the reporting of zoonoses, zoonotic agents, animal population, antimicrobial resistance and food-borne outbreaks in the European Union under the Directive 2003/99/EC as well as analysing and summarising the data collected. For data collection purposes EFSA has created the Data Collection Framework application. To support reporting countries in data submission using XML/Excel/CSV data transfer, specific guidelines are given in this report covering the reporting of qualitative, quantitative and isolate-based quantitative antimicrobial resistance data in food, animals and feed as well as of prevalence data on zoonoses and food-borne contaminants, Salmonella serovar sand phagetypes, food-borne outbreak data, animal population data, disease status data and sample-based food data and text forms.