Control and eradication of bovine tuberculosis (bTB) is a challenge owing to the complex interactions between the pathogen, hosts and local environments. Modelling various bTB situations may lead to improved understanding of the ways in which different factor combinations and interactions influence occurrence, surveillance outcomes and control efforts. A conceptual framework would help to outline, from an epidemiological perspective, which factors influence bTB infection, detection and control, and how they might interact in various European situations.