Scientific Opinion on the safety evaluation of the substance, 1,3-bis(isocyanatomethyl)benzene
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- Published: 2012-08-06
- File Format: PDF
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- Size: 88.26K
- Language: English
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Introduction
This scientific opinion of EFSA deals with the risk assessment of the monomer 1,3-bis(isocyanatomethyl) benzene, CAS No. 3634-83-1, FCM Substance No 988. In water and gastric fluid simulant, immediate and complete hydrolysis of the substance to 1,3-benzenedimethanamine occurs. The toxicity of 1,3-bis(isocyanatomethyl)benzene was tested in three in vitro genotoxicity tests, with and without metabolic activation and in an in vivo micronucleus assay in rats and was considered as non-genotoxic in vivo. I
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