NATAMYCIN
Prepared at the 61st JECFA (2003) and published in FNP 52 Add 11 (2003) superseding specifications prepared at the 57th JECFA (2001) and published in FNP 52 Add 9 (2001) superseding specifications for pimaricin prepared at the 20th JECFA (1976), published in FNP 52 (1992). An ADI
0-0.3mg/kg bw was established at the 20th JECFA (1976).
SYNONYMS Pimaricin; INS No. 235
DEFINITION A fungicidal antimycotic of the polyene macrolide group. It is produced by several species of Streptomyces. The commercial product may contain up to three moles of water.
Chemical names A stereoisomer of 22-(3-Amino-3,6-dideoxy-β-D-mannopyranosyloxy)-1,3,26-trihydroxy-12-methyl-10-oxo 6,11,28 trioxatricyclo[22.3.1.05,7]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid
C.A.S. number 7681-93-8
Chemical formula C33H47NO13
Formula weight 665.74
Assay Not less than 95.0% calculated on the dried basis
DESCRIPTION White to creamy-white, almost odourless, crystalline powder
FUNCTIONAL USES Fungicidal preservative
