FAO and WHO have developed a web-based model to assess the risk associated with Enterobacter sakazakii in powdered infant formula. Use of this model does not require any specialist software other than an Internet platform. The user does not require any specialist training but will need to follow the User Manual which is available on the webpage in order to ensure correct use of the model. This model allows users to compare the impact of the implementation of different sampling plans at the end of the production of powdered infant formula and also to compare the relative impact of different preparation, storage and handling scenarios on the risk of Enterobacter sakazakii infections in infants. This is the first web-based risk assessment tool to be developed by FAO and WHO in the area of food safety.