ALITAME
Prepared at the 59th JECFA (2002), published in FNP 52 Add 10 (2002) superseding specifications prepared at the 46th JECFA (1996), published in FNP 52 Add 4 (1996), and incorporating heavy metal limits established by the 57th JECFA (2001), published in FNP 52 Add 9 (2001). An ADI of 0-1 mg/kg bw was established at the 46th JECFA (1996).
SYNONYMS INS No. 956
DEFINITION Alitame is prepared by a multistep synthesis involving the reaction between two intermediates, (S)-[2,5-dioxo-(4-thiazolidine)] acetic acid and (R)-2-aminoN-(2,2,4,4-tetramethyl-3-thietanyl)propanamide. The final product is isolated and purified through crystallization of an alitame / 4-methylbenzenesulfonic acid adduct followed by additional purification steps, and finally recrystallization from water as the 2.5 hydrate.
Chemical names L-α-Aspartyl-N-(2,2,4,4-tetramethyl-3-thietanyl)-D-alaninamide, hydrated
C.A.S. number 99016-42-9 (hydrated form) 80863-62-3 (anhydrous form)
Chemical formula C14H25N3O4S · 2.5 H2O
Formula weight 376.5 (hydrated form)
Assay Not less than 98.0% and not more than 101.0% on the anhydrous basis
DESCRIPTION White, crystalline powder, odourless or having a slight characteristic odour. Approximately 2000 times sweeter than sucrose.
FUNCTIONAL USES Sweetener
