CAC/MISC 5-1993 Glossary of Terms and Definitions (Veterinary Drugs Residues in Foods)
The Glossary of Terms and Definitions has been elaborated by the Codex Committee on Residues of Veterinary Drugs in Foods (CCRVDF) with a view towards providing information and guidance to the Committee, and is intended for internal Codex use only.
The Glossary is intended to be an open list which is subject to review by the CCRVDF in order to update, modify or add to the list of terms. Relevant terms elaborated by other Codex Committees are included. Attention is drawn to the Notes following.
1. Acceptable Daily Intake (ADI): An estimate by JECFA of the amount of a veterinary drug, expressed on a body weight basis, that can be ingested daily over a lifetime without appreciable health risk (standard man = 60 kg) (See Note 3).
2. Bioavailable Residues: Those residues that can be shown, by means of an appropriate method (e.g. Gallo-Torres method) to be absorbed into systemic circulation when fed to laboratory animals (See Note 3).
3. Bound Residue: Residues derived from the covalent binding of the parent drug or a metabolite of the drug and a cellular biological soluble or insoluble macromolecule. These residues are not extractable from the macromolecule by exhaustive extraction, denaturation or solubilization techniques. They do not result from the incorporation of metabolized, radiolabelled fragments of the drug into endogenous
