AOAC Official Method 932.21 Iodine in Drugs
Titrimetric Method
First Action 1932
Final Action
Transfer laboratory sample containing £0.1 g iodide (0.05 g is ample) to crucible, preferably Ni. If laboratory sample contains only slight amount of organic material, add 1 g starch. Add 2–3 g solid KOH. If laboratory sample is solid, add 10–15 mL alcohol before adding KOH. Alkali must be thorougly mixed with laboratory sample to prevent loss of I2 in furnace (either stir, leaving stirring rod in crucible, or heat and swirl on steam bath until KOH is in solution).Dry and char thoroughly. (Use as low temperature as possible to prevent loss of I2; £525°C.) Extract charred mass with hot H2O, filter
into Erlenmeyer, and wash well with hot H2O.
